Search on: SOLUTE CARRIER FAMILY 12, MEMBER 1 
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Descriptor English:   Solute Carrier Family 12, Member 1 
Descriptor Spanish:   Miembro 1 de la Familia de Transportadores de Soluto 12 
Descriptor Portuguese:   Membro 1 da Família 12 de Carreador de Soluto 
Synonyms English:   BSC1 Transport Protein
Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2
Kidney-Specific Na-K-Cl Symporter
NKCC2 Cotransporter
NKCC2 Protein
SLC12A1 Cotransporter
SLC12A1 Protein
Cotransporter, NKCC2
Cotransporter, SLC12A1
Kidney Specific Na K Cl Symporter
Na-K-Cl Symporter, Kidney-Specific
Protein, BSC1 Transport
Protein, NKCC2
Protein, SLC12A1
Symporter, Kidney-Specific Na-K-Cl
Transport Protein, BSC1  
Tree Number:   D12.776.157.530.450.625.750.500
D12.776.157.530.937.750.500
D12.776.543.585.450.625.750.500
D12.776.543.585.937.875.500
Definition English:   Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME. 
See Related English:   Bartter Syndrome
 
History Note English:   2014 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   55323 
Unique Identifier:   D064466 

Occurrence in VHL: 		 

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